Sheldon Milstien, PhD

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Role of Sphingosine-1-Phosphate in Health and Diseases

  • Ph.D. 1968, University of Southern California

  • 1968-1973, National Institutes of Health


The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, inflammation, atherosclerosis, diabetes, osteoporosis, and neurodegenerative disorders. S1P is produced in cells by two sphingosine kinase isoenzymes, SphK1 and SphK2, that we cloned and characterized. Many cells secrete S1P, which can then act in an autocrine or paracrine manner. Most of the known actions of S1P are mediated by a family of five specific G protein-coupled receptors. More recently, our lab has identified important intracellular targets of S1P involved in inflammation and cancer. Our work suggests that S1P actions are much more complex than previously thought, with important ramifications for development of therapeutics. Our goal is to further understand the complex roles of S1P in cancer, immune responses, and neurobiology. Publications

View Dr. Milstien's Publications via the National Library of Medicine's PubMed.
Sheldon Milstien, PhD
Adjunct Professor
Dept. of Biochemistry & Molecular Biology
Virginia Commonwealth University
VCU Massey Cancer Center
PO Box 980614
MCV Campus
Sanger Hall, Room 2-011
1101 E. Marshall Street
Richmond, VA 23298-0614

  •      804-828-9488
  • P. 1 804 828 9762
  • 1101 E Marshall St
  • F. 1 804 828 1473
  • Richmond, VA 23298
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