Carmen Sato-Bigbee, PhD

[View Image]

Regulation of oligodendrocyte proliferation and differentiation, signal transduction systems; mechanism of gene regulation during brain development and nervous system regeneration.

Education
  • B.S., 1979, Buenos Aires University, Argentina
  • B.S., 1979, Buenos Aires University, Argentina

Post-Doc
  • 1985-1988, Dept of Neurology, Yale Univ. School of Medicine
  • 1988-1995, Dept of Biochemistry, VCU

Research

[View Image] Our studies are focused on understanding the molecular mechanisms that control the formation of myelin, an intricate structure that insulates the neuronal axons allowing the rapid “saltatory” conduction of nerve impulses. Myelin and the myelin-making oligodendrocytes are also important regulators of plasticity and myelin formation correlates with enhanced function of the human infant and adolescent brain. Furthermore, altered myelin and oligodendrocytes have been recently associated to a variety of neurodevelopmental problems, including schizophrenia, autism, as well as dysfunction in both normal and pathological aging of the brain. Our most recent studies have identified novel regulators of oligodendrocyte development that may be affected by perinatal and adolescent exposure to opioids. Deregulation of these signaling pathways may also occur in the inflammatory environment of multiple sclerosis (MS), a disease in which myelin loss is the leading cause of neurological disability in young adults. We expect that targeting of these mechanisms could result in novel pharmacological treatments to stimulate remyelination in the damaged brain and spinal cord.
Publications

View Dr. Sato-Bigbee's Publications via the National Library of Medicine's PubMed.
Carmen Sato-Bigbee, PhD
Associate Professor Dept. of Biochemistry & Molecular Biology Virginia Commonwealth University PO Box 980614 MCV Campus Sanger Hall, Room 2-040 1101 E. Marshall Street Richmond, VA 23298-0614 USA

  •      804-828-7854
  •      csatobig@vcu.edu
  • P. 1 804 828 9762
  • 1101 E Marshall St
  • F. 1 804 828 1473
  • Richmond, VA 23298
View graphic version