Advances in medicine have dramatically increased pediatric cancer survival rates; 80% of children diagnosed with cancer will survive beyond five years, up from 58% in 1975-77 (National Cancer Institute, 2008). This victory has caused attention to shift from a focus on pediatric cancer as a terminal illness to consideration of cancer as a chronic illness. We are fortunate now to be able to look at ways to help children enjoy a better quality of life as they survive pediatric cancer. The overall purpose of this short-term, longitudinal investigation was to begin to delineate factors that may influence children’s quality of life by examining what happens as children and their caregivers face diagnosis and treatment of pediatric cancer. This research was funded by a K99/R00 award to Marcia Winter from the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health.