October 9, 2019
Heather R. Lucas, Ph.D., an assisstant professor in the Department of Chemistry at Virginia Commonwealth University in the College of Humanities and Sciences, has received a $1.65 million National Institues of Health grant to study the impact of brain metals such as iron and copper on a protein implicated in Parkinson's Disease.
Professor standing with her 2019 Research Group [View Image]
Parkinson’s is the most common movement disorder and the second most common neurodegenerative disorder (after Alzheimer’s disease). The biochemical mechanisms associated with how an excess or scarcity of these metals contribute to the disease are unknown, so the Lucas research group is investigating how brain metals change the structure of the protein α-synuclein.
“In the brain, the transition metals iron and copper can contribute to both functional and harmful biochemical pathways,” Lucas said. “Often, excess metal is thought of as being particularly problematic, however, this perspective overlooks the many functional roles that transition metals play. The exact roles of these metals, and how they interact with [α-synuclein] to prevent or promote [Parkinson’s disease] progression, remains a huge mystery.”
Lucas, who also has been funded through the Alzheimer’s and Related Diseases Research Award Fund from the Virginia Center on Aging, the American Chemical Society Petroleum Research Fund, and the VCU C. Kenneth and Dianne Wright Center for Clinical and Translational Research draws on her cross-disciplinary experience in inorganic chemistry, biophysics, microscopy, analytical biochemistry and chemical biology to answer these challenging questions.
Through this research, Lucas and her team hope to uncover new details about how Parkinson’s disease progresses on a molecular level. Advances in fundamental knowledge about the disease could inspire new targets for drug development, bringing hope to Parkinson’s patients worldwide.