Acoustic-Based Tissue Resuscitation

The technology

Market need

Current methods used to treat and prevent ischemia consist of intravenously-delivered pharmaceutical agents and invasive devices, such as the intra-aortic balloon pump. The ability to modulate blood flow easily and noninvasively is necessary for adequate treatment and prevention of ischemia.

Technology summary

This is a device to treat or prevent ischemia by rapidly increasing blood flow and, thereby, oxygen to tissues. The device delivers a low-frequency sound to the entire body or selected areas, which results in an increase in blood flow. The device is non-invasive and the effect can essentially be turned on and off. Moreover, this device could allow on-thefly programming and feedback when coupled with a method or technique which measures tissue oxygenation or blood flow. The apparatus is user-friendly and could be used by paramedics or in emergency departments, operating rooms, intensive care units, and in the home.

Chart showing acoustical modulation of blood flow [View Image]

Technology status

Pilot animal studies are underway.

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  • User-friendly
  • Non-invasive
  • Portable
  • Can be turned on and off
  • Low-frequency
  • Rapid increase in tissue blood flow


  • Treatment and prevention of tissue ischemia
  • Treatment of occlusion and ischemia related to hemorrhagic shock
  • Cardiogenic shock
  • Congestive heart failure, cardiac arrest
  • Septic shock

Additional information


  • Martin Lenhardt, Ph.D.
  • Kevin Ward, Ph.D

Patent status:

U.S. Patents issued: 8,197,427.

License status:

This technology is available for licensing to industry for further development and commercialization.



VCU Tech #:


Contact us about
this technology

Afsar Mir
Licensing Associate
(804) 827-2213