Drug Delivery Methods
A novel modular drug delivery platform
This technology presents a novel family of clickable oxetane-based polymers as a modular drug delivery platform. These polymer-drug conjugates are fast and easy to synthetize at low cost and allow for targeted drug release with improved therapeutic effect during drug delivery. The oxetane-based polymers are very versatile and can be used to improve delivery of various drugs and genetic constructs, which might be toxic or insoluble on their own. Using the Camptothecin (CPT) as a proof of concept, in vitro studies performed by VCU researchers have shown the quick uptake of the conjugate by the cells and its distribution into desired areas.
Furthermore, the oxetane- conjugated molecule was approximately 30 times less toxic than the unmodified one. This technology significantly improves the precision of controlled synthesis and provides a new means for the delivery system. In vitro data have demonstrated lower toxicity, better solubility and quicker uptake of modified therapeutics.
Graphic illustrating click reaction [View Image]
- Simple, fast, and cost efficient synthesis
- Versatile and flexible (can be used for various molecules)
- Targeted drug release and improved therapeutic effect
- Increased absorption and solubility
- Specific recognition of disease-related cell antigens or receptors
- Drug delivery: controlled-release therapeutic properties
- Gene delivery
- Polymer synthesis
- $10,000 conversion fee
- Royalty rate of 3% (2% for VA companies)
- For VA start-ups, royalty free for first $100,000 in sales; 2% thereafter
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- Hu Yang, Ph.D.
- Olga Zolotarska, Ph.D.
- Kenneth Wynne, Ph.D.
- Kristoffer Valerie, Ph.D.
U.S. Patent Issued
This technology is available for licensing to industry for further development and commercialization.
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Koffi Selom Egbeto, M.S.