Biomedical, Engineering and physical science

In-Situ Preservation Bridge Solution and Device for Non-Heart Beating Donors

The technology

Market need

There are more than 90,000 patients in U.S waiting for donor organs, two thirds of which are on the national kidney waiting list. In the year 2005, only 16,477 kidney transplants were performed. Currently, there are no effective methods for preserving and bridging organs from non-heart beating donors. Due to the lack of preservation methods, most kidneys harvested from these donors are not usable for transplantation due to exposure to lethal warm ischemia.

Technology summary

This invention provides an in-situ flush solution that activates known biochemical pathways in kidney cells so that they can survive the fatal warm ischemic period prior to harvest. Activation of these survival mechanisms provides the time necessary for the kidneys to be harvested and preserved with conventional techniques. This system is minimally invasive, effective, and has the potential of being used by ER physicians and trauma surgeons. Therefore, it has the potential to greatly expand the donor pool of available kidneys. This invention also has the potential to be applied to ex-vivo donation of intestine, liver, heart, and pancreas. It may also be useful in preserving organs from conventional, heart beating donors by enhancing the storage environment and in preserving organs from other extended criteria donors. As proven in animal experimentation, there is a clear and significant advantage to using the bridge flushing in-situ for non-heart beating kidney donation.

Illustration showing the in-situ flush solution [View Image]

Technology status

Preclinical testing in large animal transplant models

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Benefits:

  • Expands the donor pool of kidneys to include otherwise discarded organs
  • Increases the survival time of organs prior to harvest
  • Relatively non-invasive and effective as a bridge to conventional preservation

Applications:

  • Preservation of kidneys in non-heart beating donors
  • Potential preservation of other organs in non-heart beating donors

Additional information

Investigators:

Martin Mangino, Ph.D.

Patent status:

US patent pending (Serial No. 12/159,923).

License status:

This technology is available for licensing to industry for further development and commercialization.

Category:

Biomedical, Engineering and physical science

VCU Tech #:

06-003

Contact us about
this technology

Magdalena K. Morgan, Ph.D.
Licensing Associate
mkmorgan@vcu.edu
(804) 827-6095