Novel Dendrimer Hydrogels for Controlled Cellular Mechanics
This invention uses a highly efficient Michael-addition reaction to produce dendrimer hydrogels with modular physical and chemical properties. These new hydrogels have controlled mechanical property, network structure and swelling behavior. The production process is rapid without the use of a catalyst. The hydrogels are modulated to react to certain stimuli properties such as pH, light, enzymes and heat, to name a few. The gelation of the hydrogel shows a very high efficiency due to the reaction implemented. This novel hydrogel has multiple facets which can be applied to fields such as controlled drug delivery, targeted cell adhesion and tissue engineering.
Figure 1. The structure, property, and application of the novel dendrimer hydrogels.
- Controlled mechanical property, network structures, and swelling behavior
- Rapid process without the use of a catalyst
- Modulated to obtain properties to respond to stimuli such as pH, light, enzymes, and heat
- Tissue engineering and regeneration
- Controlled cell adhesion and drug delivery
- $10,000 conversion fee
- Royalty rate of 3% (2% for VA companies)
- For VA start-ups, royalty free for first $100,000 in sales; 2% thereafter
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Hu Yang, Ph.D.
Juan Wang, Ph.D.
Patent issued: U.S. rights are available. 15/584,622
This technology is available for licensing to industry for further development and commercialization.
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Koffi Selom Egbeto, M.S.