The VCU Genomics Core provides state-of-the-art lab-technical genomic services and analysis support to advance genomic research at VCU and beyond.
The VCU Genomics Core, directed by Karolina Aberg, Ph.D., and Gregory Buck, Ph.D., delivers comprehensive instrumentation and technical support for all aspects of genomic analysis to the research community.
Staffed by Ph.D. and M.S. trained sequencing engineers and laboratory specialists, the core offers a wide variety of services via a traditional fee-for-service model and novel collaborative solutions that involve do-it-yourself (DIY) genomics and lab-expertise for hire. These novel models give investigators opportunity for training and hands-on time on selected instrumentation and permit investigators to purchase tech-time from experienced staff to contribute to protocol development and optimization of new approaches. Staff can assist in experimental planning and project design.
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The VCU Genomics Core’s new business model offers a broad range of off-the-shelf, state-of-the-art services as well as the ability to develop and tailor protocols for specific research projects. To initiate a service request or to schedule a discussion about an ongoing or upcoming project please email us: firstname.lastname@example.org.
Published work using data generated by the Genomics Core should include the following in the acknowledgment:
“The data included in this study was generated at the Genomics Core facility at Virginia Commonwealth University.”
Include the following text in the Facilities and Resources section of grant applications when proposing to conduct work that utilizes the Genomics Core:
The VCU Genomics Core, directed by Drs. Karolina Aberg and Gregory Buck, provides comprehensive instrumentation and technical support for all aspects of genomics analysis. Staffed by Ph.D. and M.S. trained sequencing engineers and laboratory specialists, the core provides a variety of services via a traditional fee-for-service model and novel collaborative solutions that involve do-it-yourself (DIY) genomics. Investigators gain opportunities for hands-on time on selected instrumentation, lab-expertise for hire to assist with protocol development, and optimization of new approaches. Staff can assist in experimental planning and project design.
The facility, located in Sanger Hall on the MCV campus, maintains a significant portfolio of instrumentation in support of next-generation sequencing (NGS). In addition to a broad range of instruments for sample/library preparation and quality control, the core hosts four Illumina platforms including a NextSeq2000, two MiSeq instruments and a HiSeq4000, for which the sequencing configuration range from 1 x 50 bp single end (SE) to 2 x 300 bp paired end (PE) sequencing. For long read sequencing, the core maintains a Sequel instrument from Pacific Biosciences, which provides reads up to 100 kilobases in length. Commonly provided services include de novo sequencing, amplicon sequencing, whole genome sequencing (WGS), whole exome sequencing (WES), whole genome bisulfite sequencing (WGBS), methyl-binding domain sequencing (MBD-seq), transcriptome sequencing (RNA-seq), small RNA-seq (microRNA, non-coding RNAs), chromatin immunoprecipitation sequencing (ChIP-seq), targeted genome sequencing, and mitochondrial sequencing. The core also provides comprehensive microbiome analyses, including but not limited to 16 S rRNA taxonomic profiling, metagenome sequencing and metatranscriptome sequencing.
In collaboration with other VCU facilities, the core offers state-of-the-art single cell sequencing using a Chromium system from 10X Genomics; anticipates the ability to provide spatial transcriptomic analysis in Summer 2021; and provides multi-petabyte level data storage for genomic data with access to dedicated server clusters for genomic analyses in the VCU High Performance Research Computing Core.