Document Type

Article

Original Publication Date

1987

Journal/Book/Conference Title

Antimicrobial Agents and Chemotherapy

Volume

31

DOI of Original Publication

10.1128/AAC.31.3.389

Comments

Originally published at http://dx.doi.org/10.1128/AAC.31.3.389

Date of Submission

October 2014

Abstract

The physiologic response to traumatic injury may alter the disposition of drugs and thereby affect their therapeutic or toxic potential. A study was conducted in 10 mongrel dogs to determine theeffect of experimental hemorrhagic shock with resuscitation on the pharmacokinetics of gentamicinand cefazolin. Single simultaneous intravenous doses of gentamicin (3 mg/kg) and cefazolin (25 mg/kg) were administered to each animal on an initial study day, after which serial blood and urine collections were performed. After 1 week, a standard hemorrhagic shock model was applied to each animal. Shock was continued for 1 h, after which the animal was resuscitated with either whole blood or saline. After stabilization for 20 min, a second dose of gentamicin and cefazolin was administered, and blood and urine were again collected. Drug clearance was not significantly altered, except for that of cefazolin after saline resuscitation, for which there was a significant increase in drug clearance. After both methods of resuscitation an increase in the volume of distribution was noted for cefazolin and gentamicin. Drug half-life was noted to be increased aftershock for cefazolin by both resuscitation methods and for gentamicin after shock by saline resuscitation. Although alterations of pharmacokinetic parameters were noted, mean concentrations of gentamicin and cefazolin in serum were similar for pre- and postshock phases.

Rights

© 1987, American Society for Microbiology

Is Part Of

Publications from the Office of the Dean of the VCU School of Pharmacy

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