• Research themes
• Collaborations
• Publications
• Work with us

Research themes

The research themes are underpinned by imaging science methodology developments, and hence there is always overlap and cross-feed in terms of methods and assays.

• Myocardial Infarction in a Rat Model Studied by MRI
• Abdominal Fat Volume Quantification
• Imaging Tumor Metabolism by PET
• In vivo Fluorescence Imaging of T-cell Trafficking

Magnetic Resonance Imaging

Myocardial infarction in a rat model studied by MRI

Cine images Day0 (Left) & Week9 (Right)





T1 maps (Left) Day0 (1610ms) & (Right) Week9 (220ms)

• Doxorubicin a chemo-therapeutic drug was injected to induce cardiomyopathy in rats.
• The disease progression was monitored by MRI, using three different experiments
  • T1 maps – to measure the change in T1 values in myocardial tissue
  • Cine imaging to measure the ejection fraction
  • Cine-tagged imaging to measure the myocardial stress
    
    

Cine imaging
of rat heart

MR angiogram
of rat brain

Imaging Traumatic Brain Injury

Anatomical images of Control (Left)
& Treated (Right) rat head

MR Angiography of Control (Left)
& Treated (Right) rat head

• TBI was induced in rats
• Hydrogel in stem cells was used to promote vascularization
• Magnetic Resonance Angiogram (MRA) was used to visualize the brain vascular structures

Abdominal Fat Volume Quantification

• RARE MRI with & without fat suppression was used to quantify abdominal fat in mice
• Untreated high-fat diet fed mice (top row) showed increase in abdominal fat volume where as shRNAi treated high-fat diet fed mice (bottom row) exhibit decrease in fat volume as a function of time.

Imaging Hemorrhagic Shock in Rats

• Hemorrhagic shock was induced in rats
• Resuscitation was done by using saline (control) and PEG
• Proton density weighted imaging

pH Imaging Using CEST-MRI

• Chemical Exchange Saturation Transfer (CEST) MRI experiments were performed in colon cancer model in mice
• Gradient echo CEST MRI was performed
• The FOV was adjusted to cover the subcutaneous tumor
• pH before and after the bicarbonate treatment was measured

Radionuclide Emission Tomography

Imaging Tumor Metabolism by PET

• Colon Tumor Metabolism (left), In vivo Therapeutic Efficacy (right)

Uptake and Retention of 124I-FIAU by the HSV1-tk PET Reporter Gene

Longitudinal Molecular Imaging of 141Cerium Oxide Nanoparticles by SPECT/CT

X-Ray CT Imaging of new born mouse pups

Optical and Photoacoustic Imaging

In vivo Fluorescence Imaging of T-cell Trafficking

Photoacoustic Imaging of Increased Intra-tumor Hemoglobin Content after Drug Treatment in Mice

• A549 lung cancer xenograft (left graph) and Spontaneous orthotopic MMTV tumors (right graph)

CMI Imaging – Mouse Pups to Large Animals

Contacts:

• Prof. Jamal Zweit, PhD, DSc (Director)
• Sundaresan Gobalakrishnan, PhD (Research Assistant Professor)