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Drug Discovery in Neurodegenerative Disorders

Shijun Zhang's Research Lab

The research in our lab is focused on drug discovery/development for CNS disorders.

Three major directions are being undertaken to development effective small molecules as disease-modifying agents and chemical probes:

1) Bivalent compounds for Alzheimer's disease;

2) Curcumin/melatonin hybrids as neuroprotectants for Alzheimer's disease; and

3) Novel NLRP3 inflammasome inhibitors for inflammatory disorders including Alzheimer's disease, multiple sclerosis, traumatic brain injury, and acute myocardial infarction.

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