Tissue engineering is a high impact area that contains a rich variety of problems ranging from the bulk-scale mechanics at the organ- and tissue-levels, down to the cell- and molecular-scales of systems biology. The Engineered Tissue Multiscale Mechanics & Modeling (ETM3) Laboratory aims to develop highly-integrative experimental-computational approaches for cardiovascular tissue engineering, in particular, for small-caliber engineered tissue vascular grafts for coronary artery bypass surgery and epicardial restraint patches for myocardium support after infarction.

ETM3 Schematic [View Image]

The ETM3 research approach is based on 3 interconnected components:

  • theoretical advancement and model development of dense connective tissue formation
  • computational modeling and in silico simulation at multiple scales (cellular-, tissue-, and implant-level)
  • pinpointed experimental research for material characterization and model validation.

To complement tissue engineering technology development, alleviate the over-reliance on inefficient empiricism, and relieve critical barriers to its progress, the research program of the ETM3 Laboratory aims to:

  • improve mechanistic understanding and help hypothesis formulation
  • complement empirical trial-and-error approaches
  • provide cost-effective methods for in silico optimization of processes and product design.

Virginia Commonwealth University

College of Engineering

Mechanical and Nuclear Engineering

401 West Main Street
Box 843015
Richmond, Virginia 23284
Phone: 804.827.3517
Email: jsoares@vcu.edu

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