September 27, 2019
The grant title is CAREER: Allosteric Activating of SIRT6 by DNA and the project period is 09/01/2019 - 08/31/2024. This study seeks to elucidate how the regulation of SIRT6 activity takes place in cells and to suggest possible strategies for effective SIRT6 activation. The concurrent aim is to provide a broadly accessible research experience for a large number of students across multiple academic levels. The comprehensive plan includes the mentoring of undergraduates, graduates and PharmD students as well as an outreach program offered to high school AP biology students. A PI-graduate student working group is to be established to develop and implement new guidelines for training in the interdisciplinary field of chemical biology.