Document Type

Article

Original Publication Date

2011

Journal/Book/Conference Title

Journal of Nanomaterials

Volume

2011

Issue

Article ID 348268, 15 pages

DOI of Original Publication

10.1155/2011/348268

Comments

Originally published at http://dx.doi.org/10.1155/2011/348268.

Date of Submission

August 2014

Abstract

Type I collagen and gelatin, a derivative of Type I collagen that has been denatured, can each be electrospun into tissue engineering scaffolds composed of nano- to micron-scale diameter fibers. We characterize the biological activity of these materials in a variety of tissue engineering applications, including endothelial cell-scaffold interactions, the onset of bone mineralization, dermal reconstruction, and the fabrication of skeletal muscle prosthetics. Electrospun collgen (esC) consistently exhibited unique biological properties in these functional assays. Even though gelatin can be spun into fibrillar scaffolds that resemble scaffolds of esC, our assays reveal that electrospun gelatin (esG) lacks intact α chains and is composed of proinflammatory peptide fragments. In contrast, esC retains intact α chains and is enriched in the α 2(I) subunit. The distinct fundamental properties of the constituent subunits that make up esC and esG appear to define their biological and functional properties.

Rights

Copyright © 2011 Balendu Shekhar Jha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Is Part Of

VCU Anatomy and Neurobiology Publications

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