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Kristoffer C. Valerie, M.S., Ph.D.

Massey Cancer Center research program membership

Developmental Therapeutics

Department affiliations

Professor, Department of Biochemistry and Molecular Biology, School of Medicine
Professor, Department of Microbiology and Immunology, School of Medicine
Professor, Department of Physics, College of Humanities and Sciences
Professor, Department of Radiation Oncology, School of Medicine

Education

PhD, Royal Institute of Technology, Sweden (1986)
MS, Temple University (1985)

Research description

The research focus in the Valerie laboratory is on brain cancer and radiation-induced neurodegeneration resulting from DNA damage and repair. Much of the effort is spent on improving the treatment of malignant glioma and testing of small molecule inhibitors as radiosensitizers targeting the ATM kinase, the master regulator of the DNA damage response. ATM kinase plays a pivotal role in the decision-making between survival and death after radiation-induced DNA damage in both tumor and healthy brain but with opposite effect. ATM is required for neuronal cell death in the latter tissue whereas an ATM inhibitor radiosensitizes the tumor. Interestingly, ATM also plays an important role in the development of human neurodegenerative disease. To better understand this dichotomy we are using rodent models developed in the lab for studying neurodegeneration caused by radiation. More specifically, current projects include: 1. Ex vivo glioblastoma multiforme (GBM) tissue study: biomarker analysis of radiation-induced DNA damage signaling in tumor tissue resected from patients with GBM 2. Immune checkpoint inhibitor in combination with AZD1390 and radiation for GBM 3. Development of a porcine brain tumor model for therapeutic experimentation 4. DNA damage response and aberrant cell cycle reentry in neurodegeneration in a novel conditional knockout mouse model

Disease focus of research

Brain & nervous system, Head & neck

Research keywords

Animal models,Apoptosis,Biomarkers,Cancer cell biology,Cancer therapy,Cell cycle regulation,Cell signaling,Clinical trials,DNA damage,Imaging,Immunotherapy,Inflammation,Mitosis,Molecular medicine,Precision medicine,Radiotherapy,Signal transduction,Targeted therapies,Translational science,Tumor microenvironment

Published research (during tenure as a Massey Cancer Center member)

Search In PubMed

Contact information

Email: kvalerie@vcu.edu

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