Course Materials: HGEN 619 [Spring 2013]

Topics for 2013 Spring Session | Syllabi Statements

Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision.

DateLecture TopicLecturerNotes and Examples
Jan 17OpenMx IntroOpenMx ScriptingUnivariate Statistics Script
Bivariate Statistics Script
Jan 28Summarizing Data, Testing Model AssumptionsSummarizing DataUnivariate Twin Saturated Continuous
Jan 30First Twin Model, Fitting Univariate ModelsFirst Twin ModelUnivariate Twin ADE Continuous
Feb 04Threshold Model, Fitting Categorical ModelsThreshold ModelsBinary WarmUp
Univariate Twin Saturated Binary
Univariate Twin ACE Binary
Feb 13LikelihoodLikelihood PDFLikelihood
Bivariate Normal
Feb 13Fitting Categorical/Ordinal ModelsWorking with Categorical DataUnivariate Twin Saturated Ordinal
Univariate Twin ACE Ordinal
Feb 18 & 20Heterogeneity ModelsGene x Sex Interaction ModelsUnivariate Twin Heterogeneity Continuous
Univariate Twin Heterogeneity Continuous +DZO
Feb 25 & 27Genotype x Environment Interaction ModelsGene x Environment Interaction Models
Purcell 2002
Medland 2008
van der Sluis 2012
Univariate Twin Moderation Continuous
Mar 25 & 27Bivariate ModelsBivariate Genetic AnalysisBivariate Twin Saturated & ACE Continuous
Apr 01 & 03Multivariate ModelsMultivariate Genetic AnalysisMultivariate Twin Saturated & ACE Continuous
Apr 08 & 10Developmental ModelsDevelopmental Genetic AnalysisDevelopmental Twin ACE Continuous
Apr 15 & 17Extended Pedigree ModelsExtended Pedigree AnalysisTwin Parent ACE
Apr 22 & 24Linkage & AssociationLinkage & AssociationLinkage Association FEQ in Mx
Linkage FEQ in Mx
Linkage FEQ in R
Linkage AEQG in R
Apr 22 & 24Twins + Measured GenotypesMeasured GenotypesTwin Association Model
Helper FunctionsGen Epi Helper Functions
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