Course Materials: HGEN 619 [Fall 2013]

Topics for 2013 Fall Session | Syllabi Statements

Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision.

DateLecture TopicLecturerNotes and Examples
Aug 28IntroGenetic Epidemiology Biometrical Genetics
Path Analysis Matrix Algebra
Matrix Algebra Script
Sep 04Summarizing Data, Testing Model AssumptionsSummarizing DataUnivariate Twin Saturated Continuous
Univariate Twin Saturated Binary
Univariate Twin Saturated Ordinal
Sep 11First Twin Model, Testing Univariate ModelsFirst Twin ModelUnivariate Twin ADE Continuous
Univariate Twin ACE Binary
Univariate Twin ACE Ordinal
Sep 18Power and SimulationPower & SimulationNormal Distribution Simulation
Test C Simulation
Run C Simulation
Power Approximation
Mean Estimates Simulation
Sep 25Heterogeneity ModelsGene x Sex Interaction ModelsUnivariate Twin Heterogeneity Continuous
Univariate Twin Heterogeneity Continuous +DZO
Oct 02Genotype x Environment Interaction ModelsGene x Environment Interaction Models
Purcell 2002 Medland 2008 van der Sluis 2012
Univariate Twin Moderation Continuous
Problem Set 1twinAceOrd_Homework2013.R
Oct 09Extended Pedigree ModelsExtendedTwinDesignTwin ACE
Twin Parent ACE
Twin Parent ACE SH
Twin Parent ACE PA
chatt4tp.ord
Oct 23Bivariate ModelsBivariate Genetic AnalysisBivariate Twin Saturated & ACE Continuous
Oct 30Multivariate ModelsMultivariate Genetic AnalysisMultivariate Twin Saturated & ACE Continuous
usski.rec
Nov 06Developmental ModelsDevelopmental Genetic AnalysisDevelopmental Twin ACE Continuous
jepq.txt
Nov 13Conditional ModelsConditional Genetic AnalysisBivariate CCC Twin ACE Ordinal
Trivariate CCC Twin ACE Ordinal
Sibling Interaction Twin ACE Ordinal
selVATSird.dat
Nov 20Linkage & AssociationLinkage & AssociationLinkage AQE
Linkage & Association AEQG
lipidsIBD.dat
Nov 27Twins + Measured GenotypesMeasured GenotypesTwin Association Model
selVATS.dat
Dec 04Miscelaneous TopicsHeath et al 1993Direction of Causation Model
Helper FunctionsGen Epi Helper Functions
Example PapersVink et al 2009 TRHG – Coffee Consumption
Medland et al 2009 Neuropsychologia – Handedness
Vinkhuyzen et al 2010 Genes, Brain & Behavior – Environmental Factors
van der Aa et al 2010 Int J Peds – Exercise
Vink et al 2010 Addictive Behaviors – Cannabis
Smit et al 2010 TRHG – Head Size
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