Course Materials: HGEN 619 [Fall 2014]

Topics for 2014 Fall Session | Syllabi Statements

Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision.

DateLecture TopicLecturerNotes and Examples
Aug 26IntroGenetic Epidemiology Biometrical Genetics Path Analysis Matrix Algebra Introduction of the DocumentationMatrix Algebra Script Algebra Exercise New Beginners Guide Script Alternative Approaches Script
Sep 02Summarizing Data, Testing Model AssumptionsSummarizing DataUnivariate Twin Saturated Continuous Univariate Binary Warm Up Univariate Twin Saturated Binary Univariate Twin Saturated Ordinal Univariate Twin Saturated Ordinal Alternative
Sep 09First Twin Model, Testing Univariate ModelsUnivariate ModelsUnivariate Twin ADE Continuous Univariate Twin ACE Binary Univariate Twin ACE Ordinal
Sep 16Power and SimulationPower & SimulationNormal Distribution Simulation Test C Simulation Run C Simulation Power Approximation Mean Estimates Simulation
Sep 23Heterogeneity ModelsGene x Sex Interaction ModelsUnivariate Twin Heterogeneity Continuous ADE Univariate Twin Heterogeneity Continuous ACE Univariate Twin Heterogeneity Continuous +DZO ACE_Rg Univariate Twin Heterogeneity Continuous +DZO ACE_Rg Alternative Univariate Twin Heterogeneity Continuous +DZO ACE_Rc
Sep 30Genotype x Environment Interaction ModelsGene x Environment Interaction Models Alternative Path Diagrams Purcell 2002 Medland 2008 van der Sluis 2012Univariate Twin Moderation Continuous Simulation SNPs Simulation Variance Components
Oct 07Extended Pedigree ModelsExtendedTwinDesign ExtendedTwinDesign pptTwin ACE Twin ACE equal thresholds Twin Parent ACE Twin Parent ACE SH Twin Parent ACE PA chatt4tp.ord
Oct 21Bivariate ModelsBivariate Genetic AnalysisBivariate Twin Saturated & ACE Continuous
Oct 28Multivariate ModelsMultivariate Genetic Analysis PDF Multivariate Genetic Analysis PPTXMultivariate Twin Saturated & ACE Continuous usski.rec
Nov 04Conditional ModelsConditional Genetic AnalysisBivariate CCC Twin ACE Ordinal Trivariate CCC Twin ACE Ordinal Sibling Interaction Twin ACE Ordinal selVATSird.dat
Nov 10Developmental ModelsDevelopmental Genetic AnalysisDevelopmental Twin ACE Continuous Developmental Twin ACE Ordinal jepq.txt
Nov 25Linkage & AssociationLinkage & AssociationLinkage AQE Linkage & Association AEQG lipidsIBD.dat
Dec 02Twins + Measured GenotypesMeasured GenotypesTwin Association Model selVATS.dat
Helper FunctionsGen Epi Helper Functions
View graphic versionView graphic version