Course Materials: HGEN 619 [Fall 2015]

Topics for 2015 Fall Session | Syllabi Statements

Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision.

DateLecture TopicLecturerNotes and Examples
Aug 25IntroGenetic Epidemiology Biometrical Genetics Path Analysis Matrix Algebra Introduction of the DocumentationMatrix Algebra Script
Algebra Exercise
New Beginners Guide Script
Alternative Approaches Script
Sep 01Summarizing Data, Testing Model Assumptions, Fitting Twin ModelsSummarizing Data & Fitting Twin ModelsUnivariate Twin Saturated Continuous Univariate Twin Saturated+Twin Continuous
Sep 08Summarizing Data, Testing Model Assumptions, Fitting Twin Models to Ordinal DataThreshold Models Summarizing Data & Fitting Twin Models to Ordinal DataUnivariate Twin Saturated Binary Univariate Twin Saturated Ordinal Univariate Twin ACE Binary Univariate Twin ACE Binary + Submodels Univariate Twin ACE Ordinal
Sep 15Heterogeneity, Gene X Sex InteractionHeterogeneity ModelsUnivariate Twin Heterogeneity ADE Univariate Twin Heterogeneity ACE Univariate Twin Heterogeneity ACE 5 groups rg Univariate Twin Heterogeneity ACE 5 groups rc
Sep 29Gene X Environment InteractionGxE Interaction ModelsUnivariate Moderated ACE 1 moderator Univariate Moderated ACE 2 moderators Bivariate Moderated ACE
Oct 13Bivariate Genetic AnalysisBivariate Genetic ModelsBivariate ACE
Oct 20Multivariate Genetic AnalysisMultivariate ModelsTwin Multivariate Continuous usski.rec
Nov 10Power & SimulationPower & SimulationsimMeanEst.R simNormDist.R powerApproximation.R testSimC.R runSimC.R
Nov 17Extended PedigreesExtended Twin DesigntwUniAceOrds.R twUniAceTOrds.R twpaUniAeOrds.R twpaUniAceOrds.R twpaUniAcefOrdsSH.R twpaUniAcefOrdsPA.R twpaUniAceiOrdsPA.R chatt4tp.ord
Nov 24Longitudinal Genetic AnalysisDevelopmental Genetic AnalysistwinDevAceCon.R jepq.txt
Dec 01Linkage and AssociationLinkage and Association AnalysistwinAqeCon.R twinAqegCon.R lipidsIBD.dat
Helper DocsGen Epi Helper Functions
LiteratureN&C92: Scope of Genetic Analysis N&C92: Biometrical Genetics Eaves et al 2005 Maes 2005 Neale et al 2009 Boomsma et al 2002 Posthuma et al 2003 vanDongen et al 2012
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