AGES Workshop – Oct. 22-26, 2012

Multivariate Genetic Modeling

TimeSpeakerTopicPresentationNotes/Examples
09:00 – 10:00Kenneth KendlerStatistical Genetics of Substance UseIntroduction
10:00 – 10:30Timothy York / Michael NealeReview 1: R & OpenMxGen Epi Helper Functions
R_Introduction.R
11:00 – 12:30Hermine Maes / Elizabeth PromReview Multivariate Genetic Factor AnalysisReviewMultivariatr
Carey BG 1988
twinMulAceOrd.RselVATSma.dat
twinCCCAceOrd.RselVATSird.dat
01:30 – 02:30Nathan Gillespie / Brad VerhulstDirection of CausationDirectionOfCausation
Lee 2012 Correlation-Causation
Lee 2012 Commentary
DOC_continuous.R
03:00 – 04:00Michael Neale / Hermine MaesComorbidityComorbidityaltform.R
bivariateBinaryACE.R
bivariateBinaryACENoCon.R
directionofCausation.R
randomMultiformity.R
threeDisorders.R
readffpairs.R
ffpairs.rec
runAll.R
comorbPlot.R

Measurement & Phenotyping

TimeSpeakerTopicPresentationNotes/Examples
08:00 – 09:00Sarah MedlandThreshold ModelingTuesdayMorning
DataPreparation
threshold.R
thresholds
twinAceBin-Traditional.R
twinAceOrd-Traditional.R
twinAceBin-FixE.R
twinAceOrd-FixE.R
twinAceOrd-FixThresholds.R
two_cat.dat
09:00 – 10:30Michael Neale / Shuanna ClarkMeasurement Invariance / UnderreportingMeasurementInvarianceMIExample.R
octomult_10aug2010.rdata
11:00 – 12:30Ryne Estabrook / Nathan GillespieFactor Scores/ Item Response ModelFactorScoringAndIRTfactorScores.R
fsData.txt
transformFactorScores.R
trueFactorScores
01:30 – 03:30Shaunna Clark / Ryne EstabrookLatent Class Analysis/Factor Mixture ModelCrosssectional_MixtureData_Oz_CAN_Sim.dat
LCA_example.R
LCA_2Classes.Rdata
LCA_example_3c.R
LCA_3Classes.Rdata
LCA_example_4c.R
LCA_4Classes.Rdata
LCAdata.R

Genes, Environment & Development

TimeSpeakerTopicPresentationNotes/Examples
08:00 – 09:00Sarah MedlandWednesdayMorning
MatrixAlgebraHandout
twinACE.R
twinACECovSex.R
twinACECovSexAge.R
prepearlier
09:00 – 10:30Mehta / Michael NealeHierarchical Mixed ModelingML-SEMinBehavioralGeneticsnLevelSEM-APracticalIntroduction
11:00 – 12:30Nathan Gillespie / Lindon EavesLatent Growth Curve ModelingLGC_modelingLGC_ordinal.R
LGC_continuous.R
growth
polychoricFunctionSim
01:30 – 03:00Shuanna Clark / Ryne EstabrookGrowth Mixture Modeling, Regime SwitchingGrowthMixtureModelingGMM_example.R
growth

Family Processes

TimeSpeakerTopicPresentationNotes/Examples
08:00 – 09:00Sarah MedlandThursdayMorning
Ordinal
twinACE.R
twinAceOrd-FixThresholds.R
09:00 – 10:00Lindon Eaves / Hermine MaesTwin-Family and Extended PedigreesExtendedTwinKishipDesigns
AGESSiblingSpouseInteraction
Siblings.R
10:00 – 10:30Hermine Maes / Lindon EavesNuclear Family, COT, ETMLcorrelations
ETdesigns
Et88-P.R
MZM
DZM
MZF
DZF
DZO
ET88-P2.R
ETdata.txt
11:00 – 12:30Brad Verhulst / Sarah MedlandSibling Models and Age Difference ModerationModeratingCovarianceTaSsim1.R
TaSdata
TaSmod.R
ModGraph.R
01:30 – 03:00Brad VerhulstBuilding Models from ScratchACE example.R

GxE Interaction

TimeSpeakerTopicPresentationNotes/Examples
08:00 – 09:00Sarah MedlandVCxEnvSimulatedSTUDENT.R
GxEdata
09:00 – 10:30Lindon Eaves / Timothy York / Sarah MedlandGenotype Environment InteractionGxE_Interaction
Purcell_2002
Purcell & Sham_2002
Medland_2009
Nature Letter 2012
binaryGE.R
GxEdata
ordinalGE.R
continuous_rGE.R
binaryGE_CI_wrong.R
badCIs
binaryGE_CI_correct.R
goodCIs
11:00 – 12:30Tim Bates / Hermine Maes / Elizabeth PromMeasured & Unmeasured GxE InteractionSEM_Measured_GenotypesUnivTwinACEGOrdExP.R
selVATS.dat
01:30 – 03:00Lindon Eaves / Michael NealeModel LimitationsSummaryNIDA_AGES_WorkshopLCA_ExampleSeparateItemsPlanB.R
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