Skip to header Skip to main navigation Skip to main content Skip to footer

Hindle Lab

Updates from the Aerosol Research Group at VCU

Facilities

Dr. Hindle’s aerosol and formulation laboratories (Smith, 461, 415, 421 – each 600 square feet) include three main equipment areas for (i) aerosol generation and characterization, (ii) solid state characterization and (iii) quantitative drug analysis.

  • Aerosol generation equipment includes the Buchi Nano Spray Dryer, the Capillary Aerosol Generator, the Small Particle Aerosol Generator, together with a number of commercial nebulizers and inhalers.
  • The laboratories are equipped with a number of cascade impactors, including the 10 and 8 stage MOUDI Cascade Impactor, the Andersen Cascade Impactor, the Electrical Low Pressure Impactor and the Next Generation Impactor, all of which are standard methodologies for aerodynamic particle sizing of aerosols.
  • The laboratory is equipped with a series of mouth-throat (MT) and tracheobronchial (TB) models that have been designed and validated for in vitro aerosol testing.
  • Aerosol particle concentration can be measured using the condensation particle counter.
  • The SprayView system is capable of oral and nasal spray pattern characterisation
  • Two breath simulators are available for use, including, the ASL 5000 (IngMar Medical), which is a fully automated adult and neonatal breath simulator, together with an in-house inhalation simulator with a computer control system, which is capable of simulating various inhalation flow rates and wave patterns.
  • For controlled temperature and humidity studies, the labs are equipped with two controlled temperature and humidity cabinets.
  • Physical characterization equipment includes the Differential Scanning Calorimeter (DSC) and Thermal Gravimetric Analyzer (TGA), both operated by the Pyris 7 Software (Perkin Elmer). We have recently added a new DVS moisture sorption balance and helium pycnometer to our equipment
  • Other characterization equipment available includes a Karl Fisher apparatus and optical microscope.
  • Scanning electron microscopy is performed using the core university facilities provided by the Dept. of Neurobiology & Anatomy Microscopy Facility, which is supported, in part, with funding from NIH-NINDS Center core grant (5P30NS047463).
  • Other equipment include rotameters, mass flow meters, compressed air source, vacuum pumps, humidifiers (Vapotherm 2000i), water baths, dry baths, oven, refrigerators, computers, lab furniture, and various durables and consumables.
  • Quantitative drug analysis is performed in labs equipped with three Waters 2695 HPLC systems with auto-samplers, column heaters and UV PDA detectors, together with a single quadrapole ZMD mass spectrometer and triple quadrapole Quattro Micro mass spectrometer.
View graphic versionView graphic version