Document Type

Article

Original Publication Date

1989

Journal/Book/Conference Title

Antimicrobial Agents and Chemotherapy

Volume

33

DOI of Original Publication

10.1128/AAC.33.6.817

Comments

Originally published at http://dx.doi.org/10.1128/AAC.33.6.817

Date of Submission

October 2014

Abstract

Extracorporeal membrane oxygenation (ECMO) has been used in more than 1,000 infants in 50 centers in the United States. The extracorporeal circuit contains approximately 400 ml of blood, an amount exceeding the blood volume of most full-term neonates. The effect of this additional blood volume on drug disposition is unknown. In this study, we determined the pharmacokinetic parameters of gentamicin in 10 infants on ECMO. Gentamicin concentrations were determined by a fluorescence polarization immunoassay. Pharmacokinetic parameters were determined from these concentrations by using a two-compartment model. Our study demonstrated a mean steady-state volume of distribution of 0.51 +/- 0.11 liters/kg, a figure similar to that in previous studies of full-term infants. The elimination half-life was found to be prolonged (mean, 573 +/- 263 min). The creatinine level in the plasma of the infants was found to be a statistically significant predictor of elimination half-life. Recommendations regarding initial dosing levels of gentamicin in infants on ECMO are made.

Rights

© 1989, American Society for Microbiology

Is Part Of

Publications from the Office of the Dean of the VCU School of Pharmacy

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