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Rakesh Kukreja, M.S., Ph.D.

Massey Cancer Center research program membership

Developmental Therapeutics

Department affiliations

Professor and Eminent Scholar, Department of Biochemistry and Molecular Biology, School of Medicine
Professor and Eminent Scholar, Department of Emergency Medicine, School of Medicine
Professor and Eminent Scholar, Department of Physiology and Biophysics, School of Medicine
Professor and Eminent Scholar, Division of Cardiology, Department of Internal Medicine, School of Medicine

Endowed and distinguished chair or professorship

Eric Lipman Research Professorship in Cardiology

Education

PhD, Kurukshetra University, India (1982)
MS, Allahabad University, India (1977)

Research description

My major area of interest is cardiology-oncology. One of our projects (funded by the DOD) is focused on investigating novel mechanisms by which androgen deprivation therapy (ADT) for prostate cancer induces cardiac and skeletal muscle dysfunction in mice. We are also studying novel therapeutic approaches, including PDE5 inhibitors (like sildenafil) to attenuate cardiotoxicity associated with ADT. Our second project is focused on studying the combination therapy of mTOR inhibitor (rapamycin) and PDE5 inhibitor (sildenafil) in protection against doxorubicin cardiotoxicity and enhanced killing of breast cancer cells.

Disease focus of research

Breast, Prostate

Research keywords

Animal models,Apoptosis,Cardiotoxicity,Cell signaling,Clinical trials,Inflammation,Translational science

Published research (during tenure as a Massey Cancer Center member)

Search In PubMed

Contact information

Email: rakesh@vcu.edu

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