J. Chuck Harrell, Ph.D.
Massey Cancer Center research program membership
Assistant Professor, Department of Pathology, School of Medicine
PhD, University of Colorado (2007)
Dr. Harrell's research program focuses on identifying mechanisms that facilitate breast cancer metastasis to different vital organs. His lab utilizes in vitro, in vivo, and in silico models to study each step of the metastatic cascade. To ensure the relevance of the models, the data obtained is contrasted with genomic data from patient tumors and metastases. Current projects are 1) utilizing patient-derived-xenograft models to identify genetic drivers of metastasis, 2) contrasting how individual patient genomic profiles correspond with targeted drug response at the single-cell level, 3) determining pharmacological approaches to overcome chemotherapeutic resistance, and 4) investigating how ancestral lineage impacts cancer treatment responses.
Disease focus of research
Animal models,Bioinformatics,Cancer cell biology,Cancer disparities,Cancer therapy,Cancer therapy resistance,Drug discovery,Immunotherapy,Metastasis,Precision medicine,Proteomics,Translational science,Tumor microenvironment
Published research (during tenure as a Massey Cancer Center member)
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