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Keith C. Ellis, Ph.D.

Massey Cancer Center research program membership

Developmental Therapeutics

Department affiliations

Associate Professor, Department of Medicinal Chemistry, School of Pharmacy


PhD, University of Virginia (2004)

Research description

CtBP is a transcriptional co-regulator frequently overexpressed and associated with worse outcome in solid tumor cancers. CtBP upregulation leads to the expression of oncogenes and the transcriptional repression of tumor suppressor genes, helping to drive the development and spread of cancer. We have discovered a small molecule inhibitors of CtBP, which we call HIPP, and are currently working to translate HIPP from an early stage lead into a potential oncology therapy.

Disease focus of research

Breast, GI

Research keywords

Transcriptional co-regulator, CtBP, HIPP, drug discovery and development, rational drug design

Published research (during tenure as a Massey Cancer Center member)

Search In PubMed

Contact information


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